Blar i forfatter "Garcia, Juncal Garcia"

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    • TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1 

      Garcia, Juncal Garcia; Berge, Anne Kristin McLaren; Overå, Katrine Stange; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal Babanrao; Brech, Andreas; Abudu, Yakubu Princely; Lamark, Trond; Johansen, Terje; Sjøttem, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)
      Tripartite motif-containing protein 27 (TRIM27/also called RFP) is a multifunctional ubiquitin E3 ligase involved in numerous cellular functions, such as proliferation, apoptosis, regulation of the NF-kB pathway, endosomal recycling and the innate immune response. TRIM27 interacts directly with TANK-binding kinase 1 (TBK1) and regulates its stability. TBK1 in complex with autophagy receptors is ...

    • The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy 

      Berge, Anne Kristin McLaren; Garcia, Juncal Garcia; Sjøttem, Eva; Olsvik, Hallvard Lauritz (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-05)
      Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria ...